Hematopoietic stem cells in transit--where's the niche?

Mattias Magnusson; Hanna K A Mikkola

doi:10.1016/j.stem.2008.03.017

Hematopoietic stem cells in transit--where's the niche?

Cell Stem Cell. 2008 Apr 10;2(4):302-4. doi: 10.1016/j.stem.2008.03.017.

Authors

Mattias Magnusson¹, Hanna K A Mikkola

Affiliation

¹ Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

PMID: 18397748
DOI: 10.1016/j.stem.2008.03.017

Abstract

In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Egr1 targets may lead to better strategies to expand populations of HSCs ex vivo for therapeutic applications.

Publication types

Comment
Editorial

MeSH terms

Animals
Cell Movement / physiology
Cell Proliferation
Early Growth Response Protein 1 / physiology
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / physiology
Humans

Substances

EGR1 protein, human
Early Growth Response Protein 1
Egr1 protein, mouse