The CDC and other public health organizations have identified numerous disparities in the incidence and outcomes of HIV disease among different population groups. Data suggest that some disparities are expected and unavoidable (eg, HIV incidence by age), while others imply inequalities or inequalities that are potentially remediable (eg, differential access by race or sex to HIV prevention and treatment services). Women and minorities, especially those in South and rural areas, have recently been identified as underserved populations at high risk for increased morbidity and mortality from HIV/AIDS. This article reviews current epidemiological trends in HIV/AIDS outcomes, key contributors to observed and emerging health disparities, and strategies that are being employed to overcome important modifiable disparities.