Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain

FEBS Lett. 1991 Jan 28;278(2):211-6. doi: 10.1016/0014-5793(91)80119-n.

Abstract

A rat brain cDNA (Raw3) related to the Drosophila Shaw K+ channel family has been characterized. Raw3 cRNA leads to the formation of TEA-insensitive, fast inactivating (A-type) K+ channels when injected into Xenopus laevis oocytes. Raw3 channels have markedly different properties from the previously cloned rat A-type K+ channel RCK4, Raw3 channels operate in the positive voltage range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • DNA / genetics
  • Electric Conductivity
  • Membrane Glycoproteins / genetics
  • Molecular Sequence Data
  • Oocytes
  • Potassium Channels / drug effects
  • Potassium Channels / genetics*
  • Potassium Channels / physiology
  • Rats
  • Recombinant Proteins / physiology
  • Xenopus laevis

Substances

  • Membrane Glycoproteins
  • Potassium Channels
  • Recombinant Proteins
  • DNA

Associated data

  • GENBANK/X58797
  • GENBANK/X58798
  • GENBANK/X58799
  • GENBANK/X58800
  • GENBANK/X58801
  • GENBANK/X58802
  • GENBANK/X58803
  • GENBANK/X62839
  • GENBANK/X62840
  • GENBANK/X62841