Abstract
Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / pathogenicity
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Cell Differentiation / drug effects
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Cytokines / biosynthesis
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Dendritic Cells / cytology
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Dendritic Cells / drug effects*
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Dendritic Cells / immunology
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Dendritic Cells / microbiology
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Graft Rejection / prevention & control
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Humans
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Immunosuppressive Agents / adverse effects*
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In Vitro Techniques
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Inflammation Mediators / metabolism
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Mycophenolic Acid / adverse effects*
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Neutrophils / cytology
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Neutrophils / drug effects*
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Neutrophils / immunology
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Neutrophils / microbiology
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Respiratory Burst / drug effects
Substances
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Cytokines
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Immunosuppressive Agents
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Inflammation Mediators
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Mycophenolic Acid