Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States

Antimicrob Agents Chemother. 2008 Jul;52(7):2680-2. doi: 10.1128/AAC.00158-08. Epub 2008 Apr 21.

Abstract

The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 bla(KPC)-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Bacterial Proteins / genetics*
  • Base Sequence
  • DNA Primers / genetics
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial / genetics
  • Genes, Bacterial
  • Humans
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Microbial Sensitivity Tests
  • Molecular Epidemiology
  • Plasmids / genetics
  • Quinolones / pharmacology
  • United States / epidemiology
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • DNA Primers
  • DNA, Bacterial
  • Quinolones
  • beta-Lactamases
  • beta-lactamase KPC-3, Klebsiella pneumoniae