Abstract
We present experimental data that demonstrate the potential of synthetic crown ether modified peptide nanostructures to act as selective and efficient chemotherapeutic agents that operate by attacking and destroying cell membranes.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Death / drug effects
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Cell Membrane / drug effects*
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Crown Ethers / chemistry
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Crown Ethers / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Molecular Conformation
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Nanostructures / chemistry
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Peptides / chemistry
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Peptides / pharmacology*
Substances
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Antineoplastic Agents
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Crown Ethers
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Peptides