Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur

Pathol Res Pract. 2008;204(8):583-8. doi: 10.1016/j.prp.2008.02.002. Epub 2008 Apr 28.

Abstract

We report a new type of secondary malignant giant cell tumor of bone, the malignancy of which was assigned to a carcinosarcoma, i.e., osteosarcoma and squamous cell carcinoma. It occurred 25 years after curettage and bone graft surgery under the diagnosis of giant cell tumor of the right distal femur. Although secondary malignant giant cell tumor is known as a sarcoma arising at the site of a previously diagnosed giant cell tumor, this case should be regarded as a new type of secondary malignant giant cell tumor of bone.

Publication types

  • Case Reports

MeSH terms

  • Amputation, Surgical
  • Bone Transplantation
  • Carcinoma, Squamous Cell / diagnostic imaging
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / surgery
  • Carcinosarcoma / diagnostic imaging
  • Carcinosarcoma / pathology*
  • Carcinosarcoma / surgery
  • Curettage
  • Fatal Outcome
  • Femoral Neoplasms / diagnostic imaging
  • Femoral Neoplasms / pathology*
  • Femoral Neoplasms / surgery
  • Giant Cell Tumor of Bone / diagnostic imaging
  • Giant Cell Tumor of Bone / pathology*
  • Giant Cell Tumor of Bone / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local*
  • Osteosarcoma / diagnostic imaging
  • Osteosarcoma / pathology*
  • Osteosarcoma / surgery
  • Radiography
  • Terminology as Topic