Stereospecific anti SE2' fluorination of allenylsilanes: synthesis of enantioenriched propargylic fluorides

Org Biomol Chem. 2008 May 21;6(10):1731-3. doi: 10.1039/b803888k. Epub 2008 Apr 3.

Abstract

The electrophilic fluorodesilylation of enantioenriched allenylsilanes proceeds with efficient transfer of chirality. The silylation-fluorination of propargylic alcohols occurs with overall retention of stereochemistry, a result consistent with a stereospecific anti S(E)2' mechanism for the fluorination step.