Small-molecule inhibitors of islet amyloid polypeptide fibril formation

Angew Chem Int Ed Engl. 2008;47(25):4679-82. doi: 10.1002/anie.200705372.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / chemical synthesis*
  • Amyloid / chemistry
  • Amyloid / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Islet Amyloid Polypeptide
  • Microscopy, Atomic Force
  • Models, Biological
  • Molecular Structure
  • Protein Folding
  • Protein Structure, Secondary
  • Spectroscopy, Fourier Transform Infrared
  • Thiazoles / chemistry*
  • Thiazoles / pharmacology

Substances

  • 4-thioxothiazolidin-2-one
  • Amyloid
  • Islet Amyloid Polypeptide
  • Thiazoles