Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury

Mini Rev Med Chem. 2008 Apr;8(4):319-30. doi: 10.2174/138955708783955953.

Abstract

This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to "carbonyl stress" during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.

Publication types

  • Review

MeSH terms

  • Acrolein / antagonists & inhibitors*
  • Acrolein / toxicity
  • Alzheimer Disease / chemically induced
  • Alzheimer Disease / drug therapy
  • Animals
  • Atherosclerosis / chemically induced
  • Atherosclerosis / drug therapy
  • Cell Death / drug effects
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Free Radical Scavengers / therapeutic use
  • Humans
  • Hydralazine / analogs & derivatives
  • Hydralazine / chemistry
  • Hydralazine / pharmacology*
  • Liver Diseases, Alcoholic / drug therapy
  • Oxidative Stress / drug effects
  • Protective Agents / chemistry
  • Protective Agents / pharmacology*
  • Protective Agents / therapeutic use
  • Spinal Cord Injuries / chemically induced
  • Spinal Cord Injuries / drug therapy

Substances

  • Free Radical Scavengers
  • Protective Agents
  • Hydralazine
  • Acrolein