N-heterocyclic carbene (NHC)-catalyzed direct amidation of aldehydes with nitroso compounds

Org Lett. 2008 Jun 19;10(12):2333-6. doi: 10.1021/ol8004276. Epub 2008 May 14.

Abstract

NHC-catalyzed direct amidation of aldehydes with nitroso compounds is a powerful method for the synthesis of N-arylhydroxamic acids. A variety of aryl, alkyl, alkenyl, and heterocyclic aldehydes were found to give excellent yields of the corresponding N-arylhydroxamic acids. This chemistry was also extended to the synthesis of chiral N-arylhydroxamic acids by kinetic resolution of alpha-branched aldehydes, a domino amidation-redox amination reaction of acrolein, and a three-component reaction for the synthesis of N-arylaziridines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrolein / chemistry
  • Aldehydes / chemistry*
  • Aziridines / chemical synthesis*
  • Aziridines / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Molecular Structure
  • Nitroso Compounds / chemistry*

Substances

  • Aldehydes
  • Aziridines
  • Hydroxamic Acids
  • Nitroso Compounds
  • carbene
  • Acrolein
  • Methane