Type 1 interferons cool the inflamed brain

Immunity. 2008 May;28(5):600-2. doi: 10.1016/j.immuni.2008.04.006.

Abstract

Although interferon-beta is the most popular treatment for multiple sclerosis, its mechanism of action remains enigmatic. In this issue of Immunity, Prinz et al. (2008) elucidate an intriguing portrait of the pleiotropic effects of type 1 interferons in taming brain inflammation.

Publication types

  • Comment

MeSH terms

  • Adoptive Transfer
  • Animals
  • Autoimmunity
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Brain / immunology*
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Encephalomyelitis, Autoimmune, Experimental / metabolism
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Interferon-beta / immunology
  • Interferon-beta / metabolism*
  • Mice
  • Microglia / immunology
  • Microglia / metabolism
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / metabolism
  • Myelin Sheath / immunology
  • Myeloid Cells / immunology
  • Myeloid Cells / metabolism
  • Phagocytosis
  • Receptor, Interferon alpha-beta / immunology
  • Receptor, Interferon alpha-beta / metabolism*
  • Signal Transduction
  • Up-Regulation

Substances

  • Cytokines
  • Histocompatibility Antigens Class II
  • Receptor, Interferon alpha-beta
  • Interferon-beta