Abstract
Two 2-phenylbenzofurans, lespedezavirgatol (1) and lespedezavirgatal (2), and a coumestan, lespedezacoumestan (3), were isolated from the aerial parts of Lespedeza virgata, together with nine known flavonoids. Their structures were determined on the basis of spectroscopic data. The three new compounds showed strong oxygen radical absorbance capacity and potent inhibition toward lipid peroxidation in both plasma and kidney homogenate of renal failure rats.
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Ascorbic Acid / pharmacology
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Kidney / drug effects*
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Kidney / pathology
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Lespedeza / chemistry*
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Lipid Peroxidation / drug effects
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Plants, Medicinal / chemistry*
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Rats
Substances
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Antioxidants
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Benzofurans
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Coumarins
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Drugs, Chinese Herbal
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Flavonoids
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lespedezacoumestan
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lespedezavirgatal
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lespedezavirgatol
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coumestan
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Ascorbic Acid