Role of lipoprotein-associated phospholipase A2 in atherosclerosis

Curr Atheroscler Rep. 2008 Jun;10(3):230-5. doi: 10.1007/s11883-008-0036-9.

Abstract

Lipoprotein-associated phospholipase A(2)(Lp-PLA(2)) is a biomarker that can be used to assess the risk for cardiovascular disease and events. In addition to being a useful marker of a risk factor, several studies suggest that Lp-PLA(2) has a pathophysiologic role in the atherosclerotic disease process. In this article, we review this aspect and its therapeutic implications.

Publication types

  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / analysis
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / drug effects
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / physiology*
  • Acute Coronary Syndrome / enzymology
  • Atherosclerosis / diagnosis
  • Atherosclerosis / enzymology*
  • Biomarkers / analysis
  • Coronary Disease / enzymology
  • Endothelial Cells / physiology
  • Humans
  • Hypolipidemic Agents / pharmacology
  • Prognosis
  • Risk Factors
  • Stroke / enzymology

Substances

  • Biomarkers
  • Hypolipidemic Agents
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase