Abstract
Serologic diagnosis for Epstein-Barr virus (EBV) infection is problematic when patients receive exogenous immunoglobulin. We recently diagnosed primary EBV infection by detecting EBV-determined nuclear antigen (EBNA) and EBV-DNA in peripheral blood mononuclear cells (PBMC) using immunofluorescence, in situ hybridization and polymerase chain reaction (PCR) techniques in a patient with X-linked lymphoproliferative disease (XLP) who received prophylactic immunoglobulins for EBV infection. These combined techniques may be helpful for early and accurate diagnosis of EBV infection in highly vulnerable patients.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antigens, Viral / analysis
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Base Sequence
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Burkitt Lymphoma / complications
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Burkitt Lymphoma / diagnosis*
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Burkitt Lymphoma / prevention & control
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DNA, Viral / analysis
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DNA, Viral / genetics
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Epstein-Barr Virus Nuclear Antigens
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Fluorescent Antibody Technique
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / immunology
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Herpesvirus 4, Human / isolation & purification
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Humans
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Immunization, Passive
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Lymphoproliferative Disorders / complications
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Lymphoproliferative Disorders / drug therapy*
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Lymphoproliferative Disorders / microbiology
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Male
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Molecular Sequence Data
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Nucleic Acid Hybridization
Substances
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Antigens, Viral
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DNA, Viral
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Epstein-Barr Virus Nuclear Antigens