Synthesis of eudistomin C and E: improved preparation of the indole unit

Hiroaki Yamagishi; Koji Matsumoto; Kotaro Iwasaki; Tohru Miyazaki; Satoshi Yokoshima; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1021/ol800527p

Synthesis of eudistomin C and E: improved preparation of the indole unit

Org Lett. 2008 Jun 19;10(12):2369-72. doi: 10.1021/ol800527p. Epub 2008 May 23.

Authors

Hiroaki Yamagishi¹, Koji Matsumoto, Kotaro Iwasaki, Tohru Miyazaki, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama

Affiliation

¹ Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.

PMID: 18498172
DOI: 10.1021/ol800527p

Abstract

An improved synthesis of the indole unit, a key intermediate for eudistomin C, was established utilizing Makosza's indole synthesis. A concise total synthesis of eudistomin E was achieved on the basis of the improved synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbolines / chemical synthesis*
Indoles / chemical synthesis*
Indoles / chemistry
Molecular Structure
Urochordata / chemistry

Substances

Carbolines
Indoles
eudistomin C
eudistomin E