How to introduce radioactive chlorine into a benzene ring using [*Cl]Cl-?

Appl Radiat Isot. 2008 Oct;66(10):1341-5. doi: 10.1016/j.apradiso.2008.04.011. Epub 2008 Apr 22.

Abstract

The aim of this study was how to introduce radioactive chlorine (*Cl) isotope into a benzene ring to afford *Cl-labeled chlorobenzene ([*Cl]1). Using tributylphenylstannyl compound (2) as a starting material, we determined two routes for introducing *Cl into the benzene ring: reaction of [*Cl]Cl(-) with 2 in the presence of chloramine-T and nucleophilic reaction of [*Cl]Cl(-) with diphenyliodonium tosylate (3). The two routes provide suitable tools to prepare [*Cl]1 without electron-abstracting group in the benzene ring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzene / chemistry*
  • Chlorine / chemistry*
  • Isotope Labeling / methods*
  • Radioisotopes / chemistry*

Substances

  • Radioisotopes
  • Chlorine
  • Benzene