Brief communication: pituitary volume and function in competing and retired male boxers

Ann Intern Med. 2008 Jun 3;148(11):827-31. doi: 10.7326/0003-4819-148-11-200806030-00005.

Abstract

Background: Pituitary consequences of chronic head trauma in boxing have not been investigated in detail.

Objective: To investigate the pituitary function in retired or active amateur boxers.

Design: Cross-sectional, observational study.

Setting: Turkey.

Participants: 61 actively competing (n = 44) or retired (n = 17) male boxers of the Turkish National Boxing Team.

Measurements: Body composition variables, pituitary volume (in 38 of 61 boxers), and pituitary function.

Results: 9 of 61 boxers (15%) had growth hormone (GH) deficiency and 5 of 61 boxers (8%) had adrenocorticotropic hormone deficiency. All boxers with GH deficiency except 1 were retired from boxing. Of 17 retired boxers, 8 (47%) had GH deficiency. Retired boxers with GH deficiency had significantly lower pituitary volume than retired boxers with normal GH.

Limitation: Pituitary volume was measured in only 38 of 61 boxers, and the study had no comparison group.

Conclusion: This study suggests that retired boxers have a high rate of pituitary dysfunction. Therefore, investigation of pituitary function in boxers, particularly retired ones, is recommended.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenocorticotropic Hormone / deficiency
  • Adult
  • Body Composition
  • Boxing / injuries*
  • Brain Concussion / pathology
  • Brain Concussion / physiopathology
  • Brain Injury, Chronic / blood
  • Brain Injury, Chronic / pathology*
  • Brain Injury, Chronic / physiopathology*
  • Cross-Sectional Studies
  • Human Growth Hormone / deficiency
  • Humans
  • Lipids / blood
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Observation
  • Pituitary Function Tests
  • Pituitary Gland / pathology*
  • Pituitary Gland / physiopathology*
  • Turkey

Substances

  • Lipids
  • Human Growth Hormone
  • Adrenocorticotropic Hormone