Synthesis and biological activity of mustard derivatives of thymine

Amel Hadj-Bouazza; Karine Teste; Ludovic Colombeau; Vincent Chaleix; Rachida Zerrouki; Michel Kraemer; Odile Sainte Catherine

doi:10.1080/15257770802086872

Synthesis and biological activity of mustard derivatives of thymine

Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):439-48. doi: 10.1080/15257770802086872.

Authors

Amel Hadj-Bouazza¹, Karine Teste, Ludovic Colombeau, Vincent Chaleix, Rachida Zerrouki, Michel Kraemer, Odile Sainte Catherine

Affiliation

¹ Laboratoire de Chimie des Substances Naturelles, Faculte des Sciences et Techniques Limoges, Universite de Limoges, France.

PMID: 18569783
DOI: 10.1080/15257770802086872

Abstract

The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Alkylating / chemical synthesis
Antineoplastic Agents, Alkylating / chemistry
Antineoplastic Agents, Alkylating / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Chemotaxis / drug effects
Humans
Matrix Metalloproteinase 2
Matrix Metalloproteinase Inhibitors
Neoplasm Invasiveness / prevention & control
Nitrogen Mustard Compounds / chemical synthesis*
Nitrogen Mustard Compounds / chemistry
Nitrogen Mustard Compounds / pharmacology*
Thymine / analogs & derivatives*
Thymine / chemistry
Thymine / pharmacology

Substances

Antineoplastic Agents, Alkylating
Matrix Metalloproteinase Inhibitors
Nitrogen Mustard Compounds
MMP2 protein, human
Matrix Metalloproteinase 2
Thymine