Abstract
The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action.
MeSH terms
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Adaptor Proteins, Signal Transducing / physiology*
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Animals
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Fasting
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Forkhead Box Protein O1
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Forkhead Transcription Factors / physiology
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Glucose / metabolism
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Insulin Receptor Substrate Proteins
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Insulin Resistance
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Intracellular Signaling Peptides and Proteins / physiology*
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Lipid Metabolism
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Liver / metabolism
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Mice
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Phosphoproteins / physiology*
Substances
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Adaptor Proteins, Signal Transducing
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Forkhead Box Protein O1
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Forkhead Transcription Factors
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Foxo1 protein, mouse
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Insulin Receptor Substrate Proteins
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Intracellular Signaling Peptides and Proteins
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Irs1 protein, mouse
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Irs2 protein, mouse
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Phosphoproteins
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Glucose