Systemic Lupus Erythematosus (SLE) is a complex multisystemic disease. Appropriate approach to lupus patients depends on a careful clinical evaluation that identifies disease activity irreversible damage co-morbid conditions and the impact of SLE on patient s health status and quality of life. The Study Group for Systemic Rheumatic Diseases (GEDRESIS) of the Portuguese Society of Rheumatology summarizes the most relevant aspects of initial evaluation and monitoring of lupus patients in a clinical protocol (PAMLES). The aim of this protocol is to provide a useful tool for application in clinical practice and to contribute to a better care of lupus patients.