Abstract
The Drosophila melanogaster TRF2 protein regulates transcription of several genes. The trf2 gene structure was studied. The gene proved to code for two protein isoforms, a known 75-kDa isoform and a newly identified 175-kDa isoform. The new isoform combines the known isoform sequence with an extended N end containing a coiled-coil motif. The long TRF2 isoform was found to act as a component of a multiprotein complex, including ISWI ATPase as well.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Triphosphatases / genetics
-
Adenosine Triphosphatases / metabolism*
-
Amino Acid Motifs / physiology
-
Animals
-
Drosophila Proteins / genetics
-
Drosophila Proteins / metabolism*
-
Drosophila melanogaster
-
Genes, Insect / physiology*
-
Multiprotein Complexes / genetics
-
Multiprotein Complexes / metabolism*
-
Protein Isoforms / genetics
-
Protein Isoforms / metabolism
-
Telomeric Repeat Binding Protein 2 / genetics
-
Telomeric Repeat Binding Protein 2 / metabolism*
-
Transcription Factors / genetics
-
Transcription Factors / metabolism*
-
Transcription, Genetic / physiology*
Substances
-
Drosophila Proteins
-
ISWI protein
-
Multiprotein Complexes
-
Protein Isoforms
-
TRF2 protein, Drosophila
-
Telomeric Repeat Binding Protein 2
-
Transcription Factors
-
Adenosine Triphosphatases