Molecular targeted therapies for breast cancer treatment

Breast Cancer Res. 2008;10(4):211. doi: 10.1186/bcr2112. Epub 2008 Jul 24.

Abstract

Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis are described. The molecular pathways and their inhibitory or repair mechanisms are discussed in the preclinical and clinical settings.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Cell Cycle
  • Cell Line, Tumor
  • ErbB Receptors / metabolism
  • Female
  • Humans
  • Models, Biological
  • NF-kappa B / metabolism
  • Neovascularization, Pathologic
  • Proteasome Endopeptidase Complex / metabolism
  • Receptor, ErbB-2 / metabolism
  • Receptors, Estrogen / metabolism
  • Signal Transduction
  • Ubiquitin / metabolism

Substances

  • NF-kappa B
  • Receptors, Estrogen
  • Ubiquitin
  • ERBB2 protein, human
  • ErbB Receptors
  • Receptor, ErbB-2
  • Proteasome Endopeptidase Complex