Abstract
Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC(50)) of 1.7 microM against CQ-resistant Dd2 strains.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amines / chemical synthesis*
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Amines / chemistry
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Amines / pharmacology*
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Ligands
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Molecular Structure
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Naphthalenes / chemistry*
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Phenol / chemical synthesis*
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Phenol / chemistry
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Phenol / pharmacology*
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Plasmodium falciparum / drug effects
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Schiff Bases / chemistry
Substances
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Amines
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Antimalarials
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Ligands
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Naphthalenes
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Schiff Bases
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naphthalene
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Phenol