A fully automated one-pot synthesis of [carbonyl-11C]WAY-100635 for clinical PET applications

Appl Radiat Isot. 2009 Jan;67(1):73-8. doi: 10.1016/j.apradiso.2008.07.008. Epub 2008 Jul 22.

Abstract

A fully automated synthesis of the important 5HT(1A) receptor radioligand, [carbonyl-(11)C]WAY-100635 (I), was developed based on the optimized one-pot "wet" synthesis procedure. A modern automated apparatus was constructed from commercially available components and operated via LabView software. In average, (906+/-525)MBq (n=94) of (I) was obtained from 40 min bombardment at 50 microA beam current within 50 min synthesis time. The specific radioactivity (SA) at the time of injection was (50.5+/-29.3)GBq/mumol (n=94).

MeSH terms

  • Carbon Radioisotopes*
  • Humans
  • Piperazines / chemical synthesis*
  • Positron-Emission Tomography*
  • Pyridines / chemical synthesis*
  • Radiopharmaceuticals / chemical synthesis
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists / chemical synthesis

Substances

  • Carbon Radioisotopes
  • Piperazines
  • Pyridines
  • Radiopharmaceuticals
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide