[2.2]Paracyclophane-derived chiral P,N-ligands: design, synthesis, and application in palladium-catalyzed asymmetric allylic alkylation

J Org Chem. 2008 Oct 3;73(19):7833-6. doi: 10.1021/jo801373r. Epub 2008 Aug 23.

Abstract

With the idea of tuning structural flexibility and rigidity, several [2.2]paracyclophane-derived P,N-ligands were designed and synthesized. A full investigation of the relationship between the ligands' structures and their abilities to induce asymmetry in palladium-catalyzed asymmetric allylic alkylations of malonates with 1,3-diphenyl 2-propenyl acetate was carried out, and high yields and enantioselectivities (i.e., 99% yield, 97% ee) were observed while using ligands bearing matched planar and central chirality.