CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

J Assist Reprod Genet. 2008 Aug;25(8):389-94. doi: 10.1007/s10815-008-9246-x. Epub 2008 Sep 2.

Abstract

Purpose: The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women.

Methods: We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing method.

Results: All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P < 0.05).

Conclusion: These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Aryl Hydrocarbon Hydroxylases
  • China
  • Cytochrome P-450 CYP1A1 / genetics*
  • Cytochrome P-450 CYP1A1 / physiology*
  • Cytochrome P-450 CYP1B1
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / physiology*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Leiomyoma / ethnology*
  • Leiomyoma / genetics*
  • Models, Statistical
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Risk
  • Sequence Analysis, DNA
  • Uterine Neoplasms / ethnology*
  • Uterine Neoplasms / genetics*

Substances

  • Cytochrome P-450 Enzyme System
  • Aryl Hydrocarbon Hydroxylases
  • CYP1B1 protein, human
  • Cytochrome P-450 CYP1A1
  • Cytochrome P-450 CYP1B1