Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3' A) in China

J Xiao; F Hu; H Xu; B Su; Y Jiang; J Luo; W Zhang; J Tan; L Jin; D Lu

doi:10.1007/BF02881713

Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3' A) in China

Sci China C Life Sci. 2000 Feb;43(1):16-20. doi: 10.1007/BF02881713.

Authors

J Xiao¹, F Hu, H Xu, B Su, Y Jiang, J Luo, W Zhang, J Tan, L Jin, D Lu

Affiliation

¹ Institute of Genetics, Fudan University, Shanghai, China. xiao-junhua@fudan.edu

PMID: 18763111
DOI: 10.1007/BF02881713

Abstract

CCR5-Delta32, CCR2-64I, mutants in two chemokine receptors and SDF1-3'A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Delta 32 was observed. CCR2-64I and SDF1-3' A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.