Treatment failure in Haemophilus influenzae due to a beta-lactamase low-level ampicillin-resistant organism

Vishnu van der Ploeg; Luc B S Gelinck; Iris J A M Jonkers; Jacqueline S Mourer; Alje P van Dam

doi:10.1016/j.jinf.2008.06.024

Treatment failure in Haemophilus influenzae due to a beta-lactamase low-level ampicillin-resistant organism

J Infect. 2008 Dec;57(6):485-8. doi: 10.1016/j.jinf.2008.06.024. Epub 2008 Sep 5.

Authors

Vishnu van der Ploeg¹, Luc B S Gelinck, Iris J A M Jonkers, Jacqueline S Mourer, Alje P van Dam

Affiliation

¹ Department of Infectious Diseases, C5-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

PMID: 18775568
DOI: 10.1016/j.jinf.2008.06.024

Abstract

Haemophilus influenzae is a rare causative organism of vertebral osteomyelitis in an adult. Cases reported in the literature were mainly caused by ampicillin-susceptible type b strains. Here we describe the first case of vertebral osteomyelitis due to a non-typeable, beta-lactamase low-level ampicillin-resistant H. influenzae strain with failure of prolonged intravenous amoxicillin treatment.

Publication types

Case Reports

MeSH terms

Aged
Amoxicillin / therapeutic use*
Ampicillin Resistance*
Anti-Bacterial Agents / therapeutic use*
Haemophilus Infections / drug therapy*
Haemophilus Infections / microbiology
Haemophilus influenzae / drug effects*
Haemophilus influenzae / enzymology
Haemophilus influenzae / isolation & purification
Humans
Male
Osteomyelitis / drug therapy*
Osteomyelitis / microbiology
Treatment Failure
beta-Lactamases / biosynthesis*

Substances

Anti-Bacterial Agents
Amoxicillin
beta-Lactamases