Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles

Andrew Scribner; Susan Meitz; Michael Fisher; Matthew Wyvratt; Penny Leavitt; Paul Liberator; Anne Gurnett; Chris Brown; John Mathew; Donald Thompson; Dennis Schmatz; Tesfaye Biftu

doi:10.1016/j.bmcl.2008.08.063

Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5263-7. doi: 10.1016/j.bmcl.2008.08.063. Epub 2008 Aug 22.

Authors

Andrew Scribner¹, Susan Meitz, Michael Fisher, Matthew Wyvratt, Penny Leavitt, Paul Liberator, Anne Gurnett, Chris Brown, John Mathew, Donald Thompson, Dennis Schmatz, Tesfaye Biftu

Affiliation

¹ SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA. andrew.scribner@scynexis.com

PMID: 18789686
DOI: 10.1016/j.bmcl.2008.08.063

Abstract

Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.

MeSH terms

Animals
Coccidiostats / chemical synthesis*
Coccidiostats / chemistry
Coccidiostats / pharmacology*
Combinatorial Chemistry Techniques
Cyclic GMP-Dependent Protein Kinases / antagonists & inhibitors
Eimeria / drug effects
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Imidazoles / pharmacology*
Molecular Structure
Protein Kinase Inhibitors / chemical synthesis
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology
Thiazoles / chemical synthesis*
Thiazoles / chemistry
Thiazoles / pharmacology*

Substances

Coccidiostats
Imidazoles
Protein Kinase Inhibitors
Thiazoles
Cyclic GMP-Dependent Protein Kinases