Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Darren Plant; Laura J Gibbons; Wellcome Trust Case Control Consortium; YEAR Consortium; BIRAC Consortium; Anthony G Wilson; Deborah E Bax; Ann W Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; Jane Worthington

doi:10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Nat Genet. 2008 Oct;40(10):1156-9. doi: 10.1038/ng.218. Epub 2008 Sep 14.

Collaborators

Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy, Willem H Ouwehand, Nilesh J Samani, John A Todd, Peter Donnelly, Jeffrey C Barrett, Paul R Burton, Dan Davison, Peter Donnelly, Doug Easton, David M Evans, Hin-Tak Leung, Jonathan L Marchini, Andrew P Morris, Chris C A Spencer, Martin D Tobin, Lon R Cardon, David G Clayton, Antony P Attwood, James P Boorman, Barbara Cant, Ursula Everson, Judith M Hussey, Jennifer D Jolley, Alexandra S Knight, Kerstin Koch, Elizabeth Meech, Sarah Nutland, Christopher V Prowse, Helen E Stevens, Niall C Taylor, Graham R Walters, Neil M Walker, Nicholas A Watkins, Thilo Winzer, John A Todd, Willem H Ouwehand, Richard W Jones, Wendy L McArdle, Susan M Ring, David P Strachan, Marcus Pembrey, Gerome Breen, David St Clair, Sian Caesar, Katherine Gordon-Smith, Lisa Jones, Christine Fraser, Elaine K Green, Detelina Grozeva, Marian L Hamshere, Peter A Holmans, Ian R Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael C O'Donovan, Michael J Owen, Nick Craddock, David A Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGuffin, Allan H Young, I Nicol Ferrier, Stephen G Ball, Anthony J Balmforth, Jennifer H Barrett, D Timothy Bishop, Mark M Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S Hall, Peter S Braund, Paul R Burton, Richard J Dixon, Massimo Mangino, Suzanne Stevens, Martin D Tobin, John R Thompson, Nilesh J Samani, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W Lees, Elaine R Nimmo, Jack Satsangi, Sheila A Fisher, Alastair Forbes, Cathryn Lewis, Clive M Onnie, Natalie J Prescott, Jeremy Sanderson, Christopher G Mathew, Jamie Barbour, M Khalid Mohiuddin, Catherine E Todhunter, John C Mansfield, Tariq Ahmad, Fraser R Cummings, Derek P Jewell, John Webster, Morris J Brown, David G Clayton, G Mark Lathrop, John Connell, Anna Dominiczak, Nilesh J Samani, Carolina A Braga Marcano, Beverley Burke, Richard Dobson, Johannie Gungadoo, Kate L Lee, Patricia B Munroe, Stephen J Newhouse, Abiodun Onipinla, Chris Wallace, Mingzhan Xue, Mark Caulfield, Martin Farrall, Anne Barton, Ian N Bruce, Hannah Donovan, Steve Eyre, Paul D Gilbert, Samantha L Hider, Anne M Hinks, Sally L John, Catherine Potter, Alan J Silman, Deborah P M Symmons, Wendy Thomson, Jane Worthington, David G Clayton, David B Dunger, Sarah Nutland, Helen E Stevens, Neil M Walker, Barry Widmer, John A Todd, Timothy M Frayling, Rachel M Freathy, Hana Lango, John R B Perry, Beverley M Shields, Michael N Weedon, Andrew T Hattersley, Graham A Hitman, Mark Walker, Kate S Elliott, Christopher J Groves, Cecilia M Lindgren, Nigel W Rayner, Nicholas J Timpson, Eleftheria Zeggini, Mark I McCarthy, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew Brown, Jayne A Franklyn, Joanne M Heward, Matthew J Simmonds, Stephen C L Gough, Sheila Seal, Michael R Stratton, Nazneen Rahman, Maria Ban, An Goris, Stephen J Sawcer, Alastair Compston, David Conway, Muminatou Jallow, Melanie Newport, Giorgio Sirugo, Kirk A Rockett, Dominic P Kwiatkowski, Suzannah J Bumpstead, Amy Chaney, Kate Downes, Mohammed J R Ghori, Rhian Gwilliam, Sarah E Hunt, Michael Inouye, Andrew Keniry, Emma King, Ralph McGinnis, Simon Potter, Rathi Ravindrarajah, Pamela Whittaker, Claire Widden, David Withers, Panos Deloukas, Hin-Tak Leung, Sarah Nutland, Helen E Stevens, Neil M Walker, John A Todd, Doug Easton, David G Clayton, Paul R Burton, Martin D Tobin, Jeffrey C Barrett, David M Evans, Andrew P Morris, Lon R Cardon, Niall J Cardin, Dan Davidson, Teresa Ferreira, Joanne Pereira-Gale, Ingeleif B Hallgrimsdóttir, Bryan N Howie, Jonathan L Marchini, Chris C A Spencer, Zhan Su, Yik Ying Teo, Damjan Vukcevic, Peter Donnelly, David Bentley, Matthew A Brown, Lon R Cardon, Mark Caufield, David G Clayton, Alistair Compston, Nick Craddock, Panos Deloukas, Peter Donnelly, Martin Farrall, Stephen C L Gough, Alistair S Hall, Andrew T Hettersley, Adrian V S Hill, Dominic P Kwiatkowski, Christopher G Mathew, Mark I McCarthy, Willem H Ouwehand, Miles Parkes, Marcus Pembrey, Nazneen Rahman, Nilesh J Samani, Michael R Stratton, John A Todd, Jane Worthington, Paul Emery, Philip Conaghan, Mark Quinn, Ann Morgan, Anne-Maree Keenan, Elizabeth Hensor, Julie Kitcheman, Andrew Gough, Michael Green, Richard Reece, Lesley Hordon, Philip Helliwell, Richard Melsom, Sheelagh Doherty, Ade Adebajo, Andrew Harvey, Steve Jarrett, Gareth Huson, Amanda Isdale, Mike Martin, Zinaid Karim, Dennis McGonagle, Colin Pease, Sally Cox, Victoria Bejarano, Jackie Nam, Claire Brown, Christine Thomas, David Pickles, Alison Hammond, Beverly Neville, Alan Fairclough, Caroline Nunns, Anne Gill, Julie Green, Belinda Rhys-Evans, Barbara Padwell, Julie Madden, Lynda Taylor, Sally Smith, Heather King, Jill Firth, Jayne Heard, Linda Sigsworth, Diane Corscadden, Karen Henshaw, Lubna-Haroon Rashid, Stephen G Martin, James I Robinson, L J Badcock, C M Deighton, S C O'Reilly, M R Regan, Snaith, G D Summers, R A Williams, J Delamere, K Douglas, N Erb, G D Kitas, R Klocke, A Pace, A Whallett, D Porter, J Hunter, M M Gordon, M Gupta, H Capell, R Sturrock, I McInnes, R Madhok, M Field, R Cooper, A Herrick, T O'Neil, A Jones, R Benitha, A Barton, S Knight, D Symmons, R M Bernstein, I N Bruce, K Hyrich, A Silman, K Gaffney, A J Macgregor, T Marshall, P Merry, D G I Scott, P W Thompson, S C Richards, R G Hull, J M Ledingham, F Mccrae, M R Shaban, A L Thomas, S Young Min, V E Abernethy, J K Dawson, M Lynch, E H Carpenter, P T Dawes, C Dowson, A Hassell, E M Hay, S Kamath, J Packham, E Roddy, M F Shadforth

Affiliation

¹ Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk

PMID: 18794857
PMCID: PMC2662493
DOI: 10.1038/ng.218

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid / genetics*
Arthritis, Rheumatoid / pathology
Case-Control Studies
Chromosome Mapping
Chromosomes, Human, Pair 10 / genetics*
Chromosomes, Human, Pair 12 / genetics*
Chromosomes, Human, Pair 22 / genetics*
Genetic Linkage
Genetic Predisposition to Disease / genetics*
Humans
Polymorphism, Single Nucleotide / genetics

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Authors

Collaborators

Affiliation

Abstract

Publication types

MeSH terms

Grants and funding