Abstract
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Animals
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Antimalarials / administration & dosage
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Artemisinins / administration & dosage
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Artesunate
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Cambodia / epidemiology
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Drug Resistance, Multiple / genetics
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Female
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Gene Dosage
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Genes, Protozoan
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Humans
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / epidemiology*
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Malaria, Falciparum / parasitology*
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Male
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Mefloquine / administration & dosage
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Multidrug Resistance-Associated Proteins / genetics
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / genetics*
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Plasmodium falciparum / isolation & purification
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Population Surveillance
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Protozoan Proteins / genetics
Substances
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Antimalarials
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Artemisinins
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Mdr1 protein, Plasmodium falciparum
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Multidrug Resistance-Associated Proteins
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Protozoan Proteins
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Artesunate
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Mefloquine