Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats

J Periodontol. 2008 Oct;79(10):1950-61. doi: 10.1902/jop.2008.080041.

Abstract

Background: The present study was designed to evaluate the effects of risedronate, one of the most potent bisphosphonates, on alveolar bone resorption and angiogenesis in rats with experimental periodontitis to identify dose-response curves and treatment durations that can be therapeutic for periodontal therapy versus those associated with osteonecrosis of the jaws.

Methods: Thirty-five rats, 25 with experimental periodontitis (groups 1 through 5) and 10 with healthy periodontium (groups 6 and 7), were divided into seven equal groups: group 1 received no treatment; groups 2 and 3 received risedronate, 0.1 and 1 mg/kg, respectively, for 3 weeks; groups 4 and 5 received risedronate, 0.1 and 1 mg/kg, respectively, for 8 weeks; and groups 6 and 7 received 0.9% NaCl for 3 and 8 weeks, respectively. Animals in groups 2 through 7 were administered treatment 5 days per week. After histologic processing, histomorphometric and stereologic analyses were carried out to estimate the number of blood vessels (NBV) and the volumetric densities of bone (Vb), marrow (Vm), osteoblasts (Vob), and osteoclasts (Voc).

Results: A total of 0.1 and 1 mg/kg risedronate for 3 weeks (groups 2 and 3) significantly increased Vb and Vob and decreased Vm more prominently in group 2 (P <0.001), whereas 1 mg/kg risedronate for 8 weeks (group 5) induced no significant improvement in these parameters compared to group 1 (P >0.05). No significant decrease in Voc was found in drug-administered groups compared to group 1 (P >0.05). A significant decrease in NBV (P <0.01) and positive correlation between NBV and Vb (r(2) = 0.941; P = 0.006) were found only in group 5.

Conclusion: A short duration of risedronate administration may be useful in inhibiting bone resorption in periodontitis, whereas excessive dosages of the drug administered in longer durations can lead to impairment of bone formation and angiogenesis.

Publication types

  • Comparative Study

MeSH terms

  • Alveolar Bone Loss / drug therapy*
  • Alveolar Process / drug effects
  • Alveolar Process / pathology
  • Animals
  • Blood Vessels / drug effects
  • Blood Vessels / pathology
  • Bone Density / drug effects
  • Bone Density Conservation Agents / administration & dosage
  • Bone Density Conservation Agents / therapeutic use*
  • Bone Marrow / drug effects
  • Bone Marrow / pathology
  • Cell Count
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Etidronic Acid / administration & dosage
  • Etidronic Acid / analogs & derivatives*
  • Etidronic Acid / therapeutic use
  • Image Processing, Computer-Assisted
  • Male
  • Neovascularization, Physiologic / drug effects*
  • Osteoblasts / drug effects
  • Osteoblasts / pathology
  • Osteoclasts / drug effects
  • Osteoclasts / pathology
  • Osteogenesis / drug effects
  • Osteonecrosis / chemically induced
  • Periodontal Attachment Loss / drug therapy
  • Periodontal Attachment Loss / pathology
  • Periodontitis / drug therapy
  • Periodontitis / pathology
  • Periodontium / drug effects
  • Placebos
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Risedronic Acid
  • Time Factors

Substances

  • Bone Density Conservation Agents
  • Placebos
  • Risedronic Acid
  • Etidronic Acid