Quantitative production of prostaglandin E2 and its metabolites by human fetal membranes

Br J Obstet Gynaecol. 1991 Jul;98(7):712-5. doi: 10.1111/j.1471-0528.1991.tb13461.x.

Abstract

Cultured amnion, choriodecidua and intact fetal membrane produced similar quantities of prostaglandin E2 (PGE2) (1-5 ng/ml). Choriodecidua and intact fetal membrane also produced very high levels of PGE2 metabolites (100-1000 ng/ml). The total production of PGE (PGE2 + PGE2 metabolites) was similar in intact fetal membrane and in choriodecidua, suggesting that the amnion, although a source of PGE2, contributes little to the overall PGE production by fetal membranes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amnion / metabolism
  • Chorion / metabolism
  • Culture Techniques
  • Dinoprostone / analysis
  • Dinoprostone / metabolism*
  • Extraembryonic Membranes / metabolism*
  • Humans

Substances

  • Dinoprostone