Primary peritonitis due to Streptococcus pyogenes with reduced susceptibility to fluoroquinolones

Alexandra Doloy; Claire Godin; Jean-Winoc Decousser; Pierre Panel; Alix Greder-Belan; Florence Doucet-Populaire

doi:10.1016/j.diagmicrobio.2008.08.001

Primary peritonitis due to Streptococcus pyogenes with reduced susceptibility to fluoroquinolones

Diagn Microbiol Infect Dis. 2008 Dec;62(4):447-9. doi: 10.1016/j.diagmicrobio.2008.08.001. Epub 2008 Oct 7.

Authors

Alexandra Doloy¹, Claire Godin, Jean-Winoc Decousser, Pierre Panel, Alix Greder-Belan, Florence Doucet-Populaire

Affiliation

¹ Microbiologie, Centre Hospitalier de Versailles, Le Chesnay 78157, France.

PMID: 18842379
DOI: 10.1016/j.diagmicrobio.2008.08.001

Abstract

We report the 1st case of primary peritonitis caused by Streptococcus pyogenes with a reduced susceptibility to fluoroquinolones in a healthy woman, leading to a clinical and microbiological treatment failure. DNA sequencing of parC and gyrA revealed the association of the following 3 substitutions in ParC: Ser80Pro, Asp91Asn, and Ser140Pro.

MeSH terms

Adult
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Multiple, Bacterial*
Female
Fluoroquinolones / pharmacology*
Humans
Peritonitis / drug therapy
Peritonitis / microbiology*
Streptococcal Infections / drug therapy
Streptococcal Infections / microbiology*
Streptococcus pyogenes / drug effects*

Substances

Anti-Bacterial Agents
Fluoroquinolones