Introduction: Hyperhomocysteinemia is an independent risk factor for premature cardiovascular disease. In this study we examined the prevalence of high plasma levels of homocysteine in different stages of chronic renal failure.
Material and methods: We examined 105 subjects: 73 patients in different stage of chronic renal failure, 31 of them on hemodialysis, and 32 subjects as a control group.
Results: The results show high prevalence of hyperhomocysteinemia in chronic renal failure patients, especially with reduction of glomerular filtration rate over 50% of the surface normalized value.
Conclusion: We can conclude that hyperhomocysteinemia is important risk factor for cardiovascular diseases in chronic renal failure patients, according to its high prevalence in these patients.