Elevated 18-hydroxy-corticosterone in inbred salt-sensitive rats

Clin Exp Hypertens A. 1991;13(3):371-82. doi: 10.3109/10641969109045057.

Abstract

Rats susceptible to the hypertensive effect of dietary salt (SS/Jr) have excess 18-hydroxydeoxycorticosterone (18-OH-DOC) and 19-nor-DOC compared to control rats (SR/Jr). This may be caused by an abnormal adrenal 11 beta-hydroxylase, which catalyzes the 11 beta, 18, and 19-hydroxylations of DOC. A comparison of the urinary products of this enzyme including 18-OH-DOC, 19-nor-DOC, corticosterone (B), and 18-OH-B have not been described in the SS/Jr. Therefore, these steroid products were measured at 7 and 12 weeks of age in 36 weanling male and female, SS/Jr and SR/Jr (n = 9 in each group), on a low-salt diet. In both the male and female SS/Jr urinary free levels of 18-OH-DOC, 19-nor-DOC, and 18-OH-B were elevated, while B was not different at 6 and 10 weeks of age. The largest increases were in 18-OH-B levels, and these levels correlated with 18-OH-DOC and B but not 19-nor-DOC. The high degree of correlation between these steroids probably reflects their closely related dependence on adrenal 11 beta-hydroxylase biosynthesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 18-Hydroxycorticosterone / urine*
  • Adrenal Glands / enzymology
  • Animals
  • Desoxycorticosterone / analogs & derivatives
  • Desoxycorticosterone / urine
  • Drug Resistance
  • Female
  • Hypertension / enzymology
  • Hypertension / etiology*
  • Hypertension / urine
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sodium Chloride / administration & dosage
  • Steroid 11-beta-Hydroxylase / metabolism

Substances

  • 18-hydroxydeoxycorticosterone
  • Desoxycorticosterone
  • Sodium Chloride
  • 19-nordeoxycorticosterone
  • 18-Hydroxycorticosterone
  • Steroid 11-beta-Hydroxylase