Virus capsid expansion driven by the capture of mobile surface loops

Structure. 2008 Oct 8;16(10):1491-502. doi: 10.1016/j.str.2008.06.014.

Abstract

The capsids of tailed-DNA bacteriophages first assemble as procapsids, which mature by converting into a new form that is strong enough to contain a densely packed viral chromosome. We demonstrate that the intersubunit crosslinking that occurs during maturation of HK97 capsids actually promotes the structural transformation. Small-angle X-ray scattering and crosslinking assays reveal that a shift in the crosslink pattern accompanies conversion of a semimature particle, Expansion Intermediate-I/II, to a more mature state, Balloon. This transition occurs in a switch-like fashion. We find that crosslink formation shifts the global conformational balance to favor the balloon state. A pseudoatomic model of EI-I/II derived from cryo-EM provides insight into the relationship between crosslink formation and conformational switching.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Capsid Proteins / chemistry*
  • Capsid Proteins / metabolism*
  • Models, Biological
  • Models, Molecular
  • Movement
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / metabolism
  • Protein Binding
  • Protein Structure, Quaternary
  • Protein Structure, Secondary
  • Virion / chemistry
  • Virion / metabolism
  • Virus Assembly / physiology*

Substances

  • Capsid Proteins
  • Multiprotein Complexes

Associated data

  • PDB/1OHG
  • PDB/2GP1
  • PDB/3DDX