OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C. difficile infection

Antimicrob Agents Chemother. 2009 Jan;53(1):261-3. doi: 10.1128/AAC.01443-07. Epub 2008 Oct 27.

Abstract

During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Bacteroides / drug effects*
  • Clostridioides difficile / drug effects*
  • Clostridium Infections / drug therapy*
  • Dose-Response Relationship, Drug
  • Glycosides / administration & dosage
  • Glycosides / therapeutic use*
  • Humans
  • Vancomycin / administration & dosage
  • Vancomycin / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Glycosides
  • OPT 80
  • Vancomycin