Duodenal ulcers dominate acute upper gastrointestinal tract bleeding in childhood: a 10-year experience from Hong Kong

J Dig Dis. 2008 Nov;9(4):199-203. doi: 10.1111/j.1751-2980.2008.00346.x.

Abstract

Objective: Systematic reports on acute upper gastrointestinal bleeding in children/adolescents are scanty. The aim of this study is to analyze its presentation, pathology and outcome in Hong Kong.

Methods: A retrospective review of the hospital database for admissions up to the age of 18 years with signs of acute upper gastrointestinal bleeding between 1 June 1996 and 31 May 2006.

Results: During the 10-year period 76 patients (55 boys) were admitted with signs of upper gastrointestinal bleeding. The median age was 13.5 (range 0.25-18) years. Melena and hematemesis were by far the most frequent presentations. Medication was implicated in 16 cases (21%) as the possible cause for the bleeding. Endoscopic findings were a duodenal ulcer in 57 (75%) patients (50 boys) and a gastric ulcer in eight (10.5%). Helicobacter pylori infection was identified in 42 (55%) patients, of which 38 were found in duodenal ulcer patients. Eleven patients (14.5%) had interventions to achieve hemostasis: six epinephrine spray only, three thermal probe and two vessel ligation. After a median follow-up time of 3.5 years six patients had a recurrent duodenal ulcer. Three patients died of unrelated illnesses.

Conclusion: Acute upper gastrointestinal tract bleeding in children and adolescents in Hong Kong is dominated by a duodenal ulcer in 75% of the patients. Acute bleeding is more frequent in boys (boy to girl ratio 2.6:1). Medication is a predisposing factor in 20% of the bleedings. Six patients (8%) have recurrent duodenal ulcers.

MeSH terms

  • Child
  • Child, Preschool
  • Duodenal Ulcer / diagnosis
  • Duodenal Ulcer / epidemiology*
  • Duodenal Ulcer / microbiology
  • Endoscopy, Gastrointestinal
  • Female
  • Helicobacter Infections / epidemiology
  • Helicobacter pylori
  • Hong Kong / epidemiology
  • Humans
  • Infant
  • Male
  • Peptic Ulcer Hemorrhage / diagnosis
  • Peptic Ulcer Hemorrhage / epidemiology*
  • Peptic Ulcer Hemorrhage / microbiology
  • Retrospective Studies
  • Sex Factors