Status of high level aminoglycoside resistant Enterococcus faecium and Enterococcus faecalis in a rural hospital of central India

Indian J Med Microbiol. 2008 Oct-Dec;26(4):369-71. doi: 10.4103/0255-0857.43582.

Abstract

Considering the emergence of high level aminoglycoside resistance (HLAR) in enterococci this study was undertaken to determine their status in a rural setting. HLAR by disc diffusion and agar dilution, beta lactamase by nitrocefin disc and vancomycin resistance by agar dilution was determined in 150 enterococcal isolates, as per NCCLS guidelines. Only two species, Enterococcus faecalis (85.5%) and Enterococcus faecium (14.7%) were recovered, mostly from blood. Forty six percent showed HLAR. Multi drug resistance and concomitant resistance of HLAR strains to beta lactams were quite high. None showed beta lactamase activity or vancomycin resistance.

MeSH terms

  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / epidemiology
  • Bacteremia / microbiology
  • Drug Resistance, Bacterial*
  • Enterococcus faecalis / drug effects*
  • Enterococcus faecalis / isolation & purification
  • Enterococcus faecium / drug effects*
  • Enterococcus faecium / isolation & purification
  • Gram-Positive Bacterial Infections / epidemiology*
  • Gram-Positive Bacterial Infections / microbiology
  • Hospitals, Rural / statistics & numerical data*
  • Humans
  • India
  • Microbial Sensitivity Tests / methods

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents