Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S Aulchenko; Ilse A Hoppenbrouwers; Sreeram V Ramagopalan; Linda Broer; Naghmeh Jafari; Jan Hillert; Jenny Link; Wangko Lundström; Eva Greiner; A Dessa Sadovnick; Dirk Goossens; Christine Van Broeckhoven; Jurgen Del-Favero; George C Ebers; Ben A Oostra; Cornelia M van Duijn; Rogier Q Hintzen

doi:10.1038/ng.251

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Nat Genet. 2008 Dec;40(12):1402-3. doi: 10.1038/ng.251. Epub 2008 Nov 9.

Authors

Yurii S Aulchenko¹, Ilse A Hoppenbrouwers, Sreeram V Ramagopalan, Linda Broer, Naghmeh Jafari, Jan Hillert, Jenny Link, Wangko Lundström, Eva Greiner, A Dessa Sadovnick, Dirk Goossens, Christine Van Broeckhoven, Jurgen Del-Favero, George C Ebers, Ben A Oostra, Cornelia M van Duijn, Rogier Q Hintzen

Affiliation

¹ Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.

PMID: 18997785
DOI: 10.1038/ng.251

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Genetic Predisposition to Disease*
Genome-Wide Association Study
Introns
Kinesins / genetics*
Multiple Sclerosis / genetics*

Substances

KIF1B protein, human
Kinesins