Abstract
Acute kidney injury (AKI) remains a significant cause of morbidity and mortality following cardiac surgery. Through a more thorough understanding of perioperative genomics and the evolving role of early biomarkers of AKI, the authors seek to improve meaningful outcomes among cardiac surgery patients. In this review, the focus will be on advances in risk stratification, evolving definitions and improving early diagnosis of AKI, identification of effective individualized therapies, and future directions.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acute Kidney Injury* / diagnosis
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Acute Kidney Injury* / etiology
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Acute Kidney Injury* / therapy
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Acute-Phase Proteins / urine
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Biomarkers / blood
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Biomarkers / urine
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Cardiac Surgical Procedures / adverse effects*
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Cystatin C / blood
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Cystatin C / urine
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Hepatitis A Virus Cellular Receptor 1
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Humans
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Interleukin-18 / urine
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Lipocalin-2
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Lipocalins / blood
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Lipocalins / urine
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Membrane Glycoproteins / urine
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Proto-Oncogene Proteins / blood
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Proto-Oncogene Proteins / urine
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Receptors, Virus
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Risk Assessment / methods
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Terminology as Topic
Substances
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Acute-Phase Proteins
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Biomarkers
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Cystatin C
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HAVCR1 protein, human
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Hepatitis A Virus Cellular Receptor 1
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Interleukin-18
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LCN2 protein, human
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Lipocalin-2
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Lipocalins
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Membrane Glycoproteins
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Proto-Oncogene Proteins
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Receptors, Virus