Neisseria meningitidis with reduced sensitivity to penicillin: observations in 10 children

Scand J Infect Dis. 1991;23(2):171-4. doi: 10.3109/00365549109023396.

Abstract

10/84 strains (11.9%) of Neisseria meningitidis isolated from blood and/or cerebrospinal fluid in children 1986-1987 had reduced sensitivity to benzylpenicillin (MICs 0.1-0.4 mg/l). Group C meningococci predominated among these strains. The clinical course was satisfactory in all cases regardless of the antibiotic treatment used, although the time to abatement of fever was prolonged compared to that of children infected with susceptible strains.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Erythromycin / therapeutic use
  • Female
  • Humans
  • Infant
  • Male
  • Meningitis / drug therapy
  • Meningitis / epidemiology
  • Meningitis / microbiology
  • Meningococcal Infections / drug therapy
  • Meningococcal Infections / microbiology
  • Microbial Sensitivity Tests
  • Neisseria meningitidis / drug effects*
  • Neisseria meningitidis / isolation & purification
  • Penicillin G / pharmacology
  • Penicillin Resistance*
  • Spain
  • Species Specificity

Substances

  • Erythromycin
  • Penicillin G