Role of nitric oxide in physiology and pathology of the gastrointestinal tract

Mini Rev Med Chem. 2008 Dec;8(14):1549-60. doi: 10.2174/138955708786786462.

Abstract

In this paper the physiological role of NO and isoforms of NOS in the gastrointestinal tract and the involvement of NO in pathological processes of digestive tract as well as the perspective of therapeutic use of NO-donating drugs and selective inhibitors of phosphodiesterase in the treatment of gastric diseases were presented.

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Gastrointestinal Tract / metabolism
  • Gastrointestinal Tract / pathology
  • Gastrointestinal Tract / physiology*
  • Gastrointestinal Tract / physiopathology*
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / physiology
  • Nitric Oxide / chemistry
  • Nitric Oxide / metabolism*
  • Nitric Oxide Donors / metabolism
  • Nitric Oxide Donors / therapeutic use
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Nitric Oxide Synthase / metabolism
  • Stomach Diseases / drug therapy
  • Stomach Diseases / pathology*
  • Stomach Diseases / physiopathology*

Substances

  • Enzyme Inhibitors
  • Isoenzymes
  • Nitric Oxide Donors
  • Nitric Oxide
  • Nitric Oxide Synthase