Comparison of efficacy between continuous hemodiafiltration with a PMMA membrane hemofilter and a PAN membrane hemofilter in the treatment of a patient with septic acute renal failure

Kenichi Matsuda; Takeshi Moriguchi; Norikazu Harii; Junko Goto

doi:10.1016/j.transci.2008.11.003

Comparison of efficacy between continuous hemodiafiltration with a PMMA membrane hemofilter and a PAN membrane hemofilter in the treatment of a patient with septic acute renal failure

Transfus Apher Sci. 2009 Feb;40(1):49-53. doi: 10.1016/j.transci.2008.11.003. Epub 2008 Dec 21.

Authors

Kenichi Matsuda¹, Takeshi Moriguchi, Norikazu Harii, Junko Goto

Affiliation

¹ Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato Chuo, Yamanashi 409-3898, Japan. matsudak@yamanashi.ac.jp

PMID: 19103511
DOI: 10.1016/j.transci.2008.11.003

Abstract

The aim of this study was to investigate whether PMMA-CHDF in the treatment of a patient with septic acute renal failure (septic ARF) is clinically relevant. Thirteen patients were treated with PMMA-CHDF. Thirteen patients were treated with PAN-CHDF. The urinary output significantly increased in PMMA-CHDF group following 24h of the treatment (p<0.05), whereas those did not improve in PAN-CHDF group. The 28-day survival was 84.6% in PMMA-CHDF group and 38.5% in PAN-CHDF group, respectively (p<0.05). We can assume that the cytokine modulation with PMMA-CHDF in the treatment of patients with septic ARF is clinically relevant.

Publication types

Comparative Study

MeSH terms

Acrylic Resins*
Acrylonitrile / analogs & derivatives*
Acute Kidney Injury / complications
Acute Kidney Injury / mortality
Acute Kidney Injury / therapy*
Aged
Disease-Free Survival
Female
Hemodiafiltration*
Humans
Male
Middle Aged
Polymethyl Methacrylate*
Retrospective Studies
Sepsis / complications
Sepsis / mortality
Sepsis / therapy*
Survival Rate

Substances

Acrylic Resins
AN-69
Polymethyl Methacrylate
Acrylonitrile