Aggressive variant of a papillary glioneuronal tumor. Report of 2 cases

J Neurosurg Pediatr. 2009 Jan;3(1):46-52. doi: 10.3171/2008.10.PEDS08242.

Abstract

Papillary glioneuronal tumors are a newly recognized type of brain neoplasm characterized by prominent pseudopapillary structures and glioneuronal elements. All prior cases have shown that these tumors have an indolent course. The authors present 2 patients with an aggressive variant of the tumor. The first patient had dissemination of her tumor and the second had local spreading. Therefore, the authors conclude that papillary glioneuronal tumors do not always behave in a strictly benign fashion.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery*
  • Carcinoma, Papillary / diagnosis
  • Carcinoma, Papillary / pathology
  • Carcinoma, Papillary / surgery*
  • Cerebral Cortex / pathology
  • Cerebral Cortex / surgery*
  • Child
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Frontal Lobe / pathology
  • Frontal Lobe / surgery*
  • Ganglioglioma / diagnosis
  • Ganglioglioma / pathology
  • Ganglioglioma / surgery*
  • Glial Fibrillary Acidic Protein / analysis
  • Humans
  • Magnetic Resonance Imaging
  • Microscopy, Electron
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery*
  • Neoplasms, Complex and Mixed / diagnosis
  • Neoplasms, Complex and Mixed / pathology
  • Neoplasms, Complex and Mixed / surgery*
  • Neoplasms, Multiple Primary / diagnosis
  • Neoplasms, Multiple Primary / pathology
  • Neoplasms, Multiple Primary / surgery*
  • Reoperation
  • Vimentin / analysis

Substances

  • Glial Fibrillary Acidic Protein
  • Vimentin