Coping with genetic testing for breast cancer susceptibility

Psychosom Med. 2009 Jan;71(1):98-105. doi: 10.1097/PSY.0b013e318190d7b4. Epub 2009 Jan 5.

Abstract

Objective: To examine how women cope with genetic testing for heightened susceptibility to breast cancer.

Methods: Participants were 126 White women (age = 44 +/- 9 years) who were participants in a larger study of genetic testing for risk of different chronic diseases. All women were at higher-than-average risk for breast cancer due to a personal and/or family history and were considering genetic testing. Distress (Symptom Checklist-90-Revised, Impact of Event Scale, Perceived Stress Scale, Spielberger State-Trait Anxiety Inventory, and the Center for Epidemiological Studies Depression Scale) was assessed at four assessments; one before and three after the decision to have genetic testing. The majority of women (n = 100) had testing. The follow-up assessments occurred at 1 week after receiving results (or 3-4 months after baseline if testing was not elected), and then at 3 and 6 months after the second assessment. Coping (Brief COPE) was measured at the first and third assessments.

Results: Coping was relatively stable over time and did not vary as a function of genetic test results. Active coping strategies were used more often by women with a personal cancer history than by women without cancer. Use of avoidant coping was reliably and positively associated with distress over time independent of cancer history and test result.

Conclusions: The identification of specific coping styles that were associated with more or less distress is useful as a means of identifying and targeting coping interventions and predicting which participants may be at risk for distress.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptation, Psychological*
  • Adult
  • Breast Neoplasms / genetics
  • Breast Neoplasms / psychology*
  • DNA Mutational Analysis / psychology
  • Female
  • Follow-Up Studies
  • Genes, BRCA1*
  • Genes, BRCA2*
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing / psychology*
  • Humans
  • Middle Aged
  • Psychotropic Drugs / therapeutic use
  • Risk
  • Severity of Illness Index
  • Stress, Psychological / etiology
  • Stress, Psychological / psychology

Substances

  • Psychotropic Drugs