Interleukin-17A and interleukin-17F: a tale of two cytokines

Immunity. 2009 Jan 16;30(1):9-11. doi: 10.1016/j.immuni.2008.12.010.

Abstract

In this issue of Immunity, Ishigame et al. (2009) show that interleukin-17A (IL-17A) mediates autoimmunity whereas both IL-17A and IL-17F are required for mucosal immunity. IL-17A may be more pathologic by inducing proinflammatory cytokines.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoimmunity*
  • Humans
  • Immunity, Mucosal*
  • Interleukin-17 / immunology
  • Interleukin-17 / physiology*

Substances

  • Interleukin-17