Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles

Andrew Scribner; Joseph A Moore 3rd; Gilles Ouvry; Michael Fisher; Matthew Wyvratt; Penny Leavitt; Paul Liberator; Anne Gurnett; Chris Brown; John Mathew; Donald Thompson; Dennis Schmatz; Tesfaye Biftu

doi:10.1016/j.bmcl.2009.01.001

Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1517-21. doi: 10.1016/j.bmcl.2009.01.001. Epub 2009 Jan 9.

Authors

Andrew Scribner¹, Joseph A Moore 3rd, Gilles Ouvry, Michael Fisher, Matthew Wyvratt, Penny Leavitt, Paul Liberator, Anne Gurnett, Chris Brown, John Mathew, Donald Thompson, Dennis Schmatz, Tesfaye Biftu

Affiliation

¹ SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA.

PMID: 19195883
DOI: 10.1016/j.bmcl.2009.01.001

Abstract

Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.

Publication types

Comparative Study

MeSH terms

Animals
Coccidiosis / drug therapy
Coccidiosis / enzymology
Coccidiosis / parasitology
Coccidiostats / chemical synthesis*
Coccidiostats / pharmacology
Cyclic GMP-Dependent Protein Kinases / antagonists & inhibitors
Eimeria tenella / drug effects
Eimeria tenella / enzymology
Eimeria tenella / growth & development
Indoles / chemical synthesis*
Indoles / pharmacology
Poultry / parasitology
Pyridines / chemical synthesis

Substances

Coccidiostats
Indoles
Pyridines
Cyclic GMP-Dependent Protein Kinases
pyridine